The increased penetration abilities of soundwaves makes ultrasound one of the premier imaging modalities for deep tissue imaging and the noninvasive diagnosis of diseased states. To improve the image quality of ultrasound images, gas-filled microbubbles can be administered to serve as ultrasound contrast agents. However, due to their size, current ultrasound contrast agents limit the use of ultrasound imaging to only studying circulation related conditions. My project involves the development of stimuli responsive nanobubbles as ultrasound contrast agents to expand and improve the use of ultrasound to study inflammation, cardiovascular disease, and cancer.