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Troy A. Brier

Troy A. Brier
Previous degree(s): 
BS, ACS-certified B.S. chemistry, The College of New Jersey
PhD start year: 
Award Year: 
Research Advisor(s): 
Zan Luthey-Schulten
Description of Research: 

Whole-cell simulation is a dynamic field focused on elucidating the driving forces affecting living cells. Stochastic gene expression has profound effects on a cell’s fate; a population of cells with identical genes can vary widely in makeup due to environmental effects. A current research project is to design cells with the minimum number of genes necessary for life and understand the underlying physical principles governing them. My research focuses on developing a kinetic model for the regulation of ptsG-mRNA (an essential sugar transporter in the minimal cell) via SgrS using experimental data coupled with the stochastic simulation software Lattice Microbes.