Chronic wasting disease (CWD) is an infectious neurodegenerative disease affecting cervids. It is the only transmissible spongiform encephalopathy (TSE) known to occur in wild populations. Like all other TSEs, CWD is caused by an infectious protein, a misfolded version of the cellular prion protein encoded by the PRNP gene. CWD spreads through infected bodily fluids and soils. CWD is now in 29 US states, with the first Illinois case identified in 2002. This study aimed to describe the resilient and susceptible haplotypes of the PRNP gene in wild white-tailed deer from three Illinois counties without CWD. Methods included DNA extraction, PCR, sequencing, and haplotype assignments from 44 samples (32 for one county and 12 from two other counties). Haplotype assignments need to continue before comparisons between counties can be made. The resulting data showed a high proportion of the susceptible wildtype haplotypes and some rare and resilient haplotypes.